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What are clopidogrel tablets?

CLOPIDOGREL (Plavix reg;) helps to prevent blood clots. It reduces the chance of having a heart attack or a stroke in people who have already had a heart attack or a stroke. Clopidogrel can also decrease the chance of a heart attack or stroke in certain groups of people at high risk for these events. Generic clopidogrel tablets are not yet available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of the following conditions:

bleeding disorder or hemophilia
liver disease
recent surgery or trauma
stomach or intestinal ulcers
an unusual or allergic reaction to clopidogrel, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding

How should I take this medicine?

Take clopidogrel tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. Do not take your medicine more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with clopidogrel?

aspirin
blood thinners such as warfarin or enoxaparin
antiinflammatory drugs such as NSAIDs (e.g., ibuprofen)
cilostazol
dipyridamole
DHEA
doxercalciferol
feverfew
fish oil (omega-3 fatty acids) supplements
garlic
ginger
ginkgo biloba
horse chestnut
fluvastatin
phenytoin
prasterone
ramelteon
tamoxifen
ticlopidine
tolbutamide
torsemide

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your physician or health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking clopidogrel?

Side effects that you should report to your prescriber or health care professional as soon as possible:

More common:

black, tarry stools
blood from vomiting
blood in urine or stools
nosebleed
red or purple spots on the skin
skin rash or itching
stomach pain

Rare:

difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat
fever
sudden weakness
swelling of your face, lips, tongue, hands, or feet
unusual bleeding or bruising, or pinpoint red spots on the skin
unusual rash, allergic reaction, or hives
unusually heavy menstrual bleeding

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

diarrhea
indigestion (heartburn)
mild stomach upset

What should I watch for while taking clopidogrel?

Visit your prescriber or health care professional for regular checks on your progress. Do not stop taking clopidogrel except on your prescriber's advice.

You may bleed more easily and it may take longer to stop bleeding when taking clopidogrel. Report any unusual bleeding to your prescriber.

Ask your prescriber or health care professional before you take non-prescription pain relievers. Do not take aspirin, aspirin-containing products, or antiinflammatory drugs such as ibuprofen (e.g, Motrin), ketoprofen (Orudis reg;), naproxen (e.g., Aleve) unless directed to do so by your prescriber or health care professional.

If you are going to have surgery or dental work, tell your prescriber or health care professional that you are taking clopidogrel.